Lipotropics (Li-po-tro-pic) are substances that affect fat metabolism in the body. The term “lipotropic” was first used in 1935 by scientists who were investigating fat metabolism in the liver. Through research from them and others, three fat burning nutrients came to be known as lipotropics: Methionine, Inositol, and Choline.
Methionine is a sulfur containing essential amino acid that plays an important role in many of the body’s functions including metabolism, liver function, and fat excretion. Methionine is also needed to produce certain amino acids which further contribute to healthy metabolism. The body cannot produce it’s own methionine.
Inositol helps to metabolize fat and aid in the redistribution of body fat. Inositol has been shown in studies to help prevent increases in fatty acids and total cholesterol in the liver. A deficiency of inositol can result in an accumulation of triglycerides in the liver, which impairs normal liver function and can lead to weight gain.
Choline is an essential nutrient that is related to the B vitamins. It is responsible for lipid (fat) metabolism and transport and has other jobs in the body related to cell membrane structure and other functions. Without choline, fats can become trapped in the liver and block metabolic functions.
Lipotropic nutrients are most often combined with B12. B12, also called cobalamin, is a water-soluble vitamin that plays many key roles supporting normal function of the brain and nervous system, and is involved in the metabolism of every cell of the human body. B12 plays an important role in fatty acid metabolism and energy production.
Because most lipotropic injections include the ingredients listed above (methionine + inositol + choline), many providers refer to the shots as MIC injections. Many physicians using lipotropic injections or MIC injections such as lipo-mino or lipostat plus have found success by combining these treatments with an oral lipotropic tablet or spray to keep blood levels elevated between injections and accelerate the weight loss benefits.
McHenry EW, Patterson JM. Lipotropic Factors. Physiological Reviews. January 1944; volume 24(issue 1): 128-167. doi:10.1152/physrev.1922.214.171.124 Retrieved from: https://www.physiology.org/doi/abs/10.1152/physrev.19126.96.36.199
Gavin G, Patterson JM, & McHenry EW. COMPARISON OF THE LIPOTROPIC EFFECTS OF CHOLINE, INOSITOL, AND LIPOCAIC IN RATS. J. Biol. Chem. 1943 148: 275. Retrieved from: http://www.jbc.org/content/148/2/275.citation
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