Studies have found that a specific type of B3, nicotinamide (NAM), has a significant effect on glucose metabolism. Nicotinamide resulted in improvements of oral glucose tolerance tests, fasting glucose, fasting insulin, and serum adiponectin.
Nicotinamide accomplished these results through increases of nicotinamide phosphoribosyltransferase (NAMPT), NAD, the NAD/NADH ratio, and SIRT1 activity. “These results demonstrate that NAM is more effective than NA on the regulation of glucose metabolism and the NAD-sirtuin pathway, which may relate to the altered mitochondrial biogenesis” (Yang, 2014).
Legere Pharmaceutical’s GlutaTonic combines the benefits of Nicotinamide with Glutathione and Inositol. Glutathione, Inositol, and Nicotinamide play key roles in cellular metabolism which can dramatically raise energy levels, strengthen the immune system, improve athletic performance, detoxify the body, aid in cellular repair and even slow down the aging process.
Yang, S., Choi, J., Kim, L., et. al. (2014). Nicotinamde improves glucose metabolism… J Nutr Biochem. https://www.sciencedirect.com/science/article/pii/S0955286313001988
Rahman, S., & Rezuanul, I. (2011). Mammalian Sirt1. Cell Communication and Signaling. https://biosignaling.biomedcentral.com/articles/10.1186/1478-811X-9-11
Satoh, A., Brace, C., Rensing, N., et. al. (2013). Sirt1 extends life span and delays aging in mice… Cell Metab. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794712/