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Cardiovascular Disease & Insulin Resistance

Heart disease is the #1 cause of death for both men and women in the U.S. and worldwide. A review of patients who survived an Acute Myocardial Infarction (AMI) sought to identify the cause of heart disease by looking for commonalities in these cases. After an analysis of almost 300 patients, the researchers were left with no choice but to conclude that insulin resistance is the only significant predictor for new cardiovascular events. “Hyperinsulinism was the most important factor associated to the occurrence of new cardiovascular events […] which emphasizes the pivotal role of insulin resistance in the physiopathologic mechanisms of atherosclerosis” (Garcia, 2011). Another analysis using a much larger population estimates that “insulin resistance is responsible for approximately 42% of myocardial infarctions” and posits that preventing or curing insulin resistance could result in a significant reduction of cardiovascular disease (Eddy, 2009).

DNS contains key ingredients which have been shown to significantly decrease blood glucose and improve insulin efficiency thereby enhancing glucose uptake & utilization.

Gymnema Sylvestre 150mg per capsule

– Gymnema has been shown to lower serum glucose and glycosylated hemoglobin (HbA1c) levels. “[Gymnema Sylvestre] (400 mg/day) was administered for 18-20 months as a supplement to the conventional oral drugs. During [Gymnema Sylvestre] supplementation, the patients showed a significant reduction in blood glucose, glycosylated haemoglobin(sic) and glycosylated plasma proteins, and conventional drug dosage could be decreased. Five of the 22 diabetic patients were able to discontinue their conventional drug and maintain their blood glucose homeostasis with [Gymnema Sylvestre] alone” (Baskaran, 1990).

– “One of the major side effects or actions of gymnema is taste alteration. Studies have shown that gymnema reduces the perception of sweetness inside the mouth” which, along with its hypoglycemic properties, may have prompted the Hindi name ‘gurmar’, or ‘sugar destroyer’ (Ulbricht, 2011).

– Gymnema Sylvestre has reduced hyperglycemia in both human and animal trials. It is believed that gymnema may act by enhancing insulin secretion through increased pancreatic β-cell number and improved cell function as well as enhanced glucose utilization.

Momordica Charantia 100mg per capsule

Momordica Charantiais believed to exert their hypoglycemic effects via stimulation of peripheral and skeletal muscle glucose utilisation, inhibition of intestinal glucose uptake, inhibition of adipocyte differentiation, suppression of key gluconeogenic enzymes, stimulation of key enzyme of HMP pathway, and preservation of islet β cells and their functions (Joseph, 2013).

– Animal studies have found that Momordica Charantia can activate AMPK, “improve glucose tolerance,” as well as “enhance insulin sensitivity and lipolysis” (Joseph, 2013).

Chromium (chloride) 100mcg per capsule

– Studies have found that intake of chromium chloride can “increase skeletal muscle insulin-stimulated GLUT4 translocation and glucose uptake” (Doerner, 2014).

– “Chromium deficiency also led to significant decreases in cyclic adenosine monophosphate (cAMP)-dependent phosphodiesterase (PDE) activity” further contributing to insulin resistance (Striffler, 1995).

Vanadyl Sulfate 7.5mg per capsule

– A study of patients with type 2 diabetes saw significantly decreased fasting glucose and saw an improvement of glucose metabolism in 54% of patients using Vanadyl Sulfate (Goldine, 2000).

 

 

 

References:

Joseph, B., & Jini, D. (2013). Antidiabetic effects of Momordica charintia (bitter melon) and its medicinal potency. Asian Pacific Journal of Tropical Disease. Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027280/

Baskaran, K., et. al. (1990). Antidiabetic effect of a leaf extract from Gymnema sylvestre. Journal of Ethnopharmacology. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/2259217

Goldfine, A., et. al. (2000). Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus. Metabolim.

Ulbricht, C., et. al. (2011). An Evidence-Based Review of Gymenma Sylvestre. Informa Healthcare, USA. Retrieved from: https://pdfs.semanticscholar.org/0767/bc8f4052caa88f8d543f68d2df4782d53fa9.pdf

Striffler, J., et. al. (1995). Chromium improves insulin response to glucose in rats. Metabolism. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/7476291

Doerner, P., et. al. (2014). Chromium chloride increases insulin-stimulated glucose uptake in the perfused rat hindlimb. Acta Physiologica (Oxford). Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/25195624

Garcia, R., et. al. (2011). Hyperinsulinemia is a predictor of new cardiovascular events in Colombian patients with a first myocardial infarction. International Journal of Cardiology. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/19923024

Eddy, D., et. al. (2009). Relationship of Insulin Resistance and Related Metabolic Variables to Coronary Artery Disease. Diabetes Care. Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628708/